Phenoxodiol

Name: Phenoxodiol
SKU: A21147
Price: 385 CNY
Rating: 5 (288 reviews)

目录号: A21147

Phenoxodiol，一种Genestein的合成类似物，激活线粒体caspase系统，抑制XIAP（一种凋亡抑制剂），并使癌细胞对Fas介导的凋亡更加敏感。

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规格	价格	库存
1mg	¥385.00	现货
2mg	¥560.00	现货
5mg	¥980.00	现货
10mg	¥1,610.00	现货
25mg	¥3,640.00	现货
50mg	¥5,740.00	现货
100mg	¥10,990.00	现货
*10mM 1mL in DMSO**	¥1,085.00	现货
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Data Sheet

SDS

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生物活性

Discription

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis.

Cell Research

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Cell Line	Type	Value	Description	References
HMEC-1	GI50	4.1 μM	Antiproliferative activity against human HMEC1 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis	[PMID: 23462711]
MDA-MB-231	GI50	31.3 μM	Growth inhibition of human MDA-MB-231 cells after 72 hrs by Alamar blue assay	[PMID: 28408225]
MDA-MB-231	IC50	33 μM	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by Alamar blue/spectrophotometric analysis	[PMID: 25189689]
MDA-MB-231	GI50	62.9 μM	Antiproliferative activity against human MDA-MB-231 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis	[PMID: 23462711]
MRC5	IC50	108.5 μM	Cytotoxicity against human MRC5 cells after 72 hrs by Alamar blue assay	[PMID: 28408225]
MRC5	GI50	109 μM	Antiproliferative activity against human MRC5 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis	[PMID: 23462711]
U-87MG ATCC	GI50	> 100 μM	Growth inhibition of human U87 cells after 72 hrs by Alamar blue assay	[PMID: 28408225]

Showing 1 to 7 of 7 entries

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产品信息

目录号	A21147
分子式	C15H12O3
分子量	240.25
CAS号	81267-65-4
SMILES	OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1
其他名称	Idronoxil; Dehydroequol; Haginin E
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	43 mg/mL (178.98 mM)
	Water	Insoluble
	Ethanol	43 mg/mL (178.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	41.62 mL	208.12 mL	416.23 mL
0.5 mM	8.32 mL	41.62 mL	83.25 mL
1 mM	4.16 mL	20.81 mL	41.62 mL
5 mM	0.83 mL	4.16 mL	8.32 mL

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