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| Catalog No. | Inhibitor Name | PDE | PDE1 | PDE2 | PDE3 | PDE4 | PDE5 | PDE6 | PDE9A | PDE10A | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A10804 | Roflumilast | **** | |||||||||
| A10216 | Cilomilast | *** | |||||||||
| A10883 | Tadalafil | *** | |||||||||
| A10733 | Pimobendan | ** | |||||||||
| A11073 | GSK256066 | **** | |||||||||
| A11191 | PF-2545920 | **** | |||||||||
| A10805 | Rolipram | ** | |||||||||
| A10217 | Cilostazol | ** | |||||||||
| A10592 | Milrinone | ** | ** | ATPase | |||||||
| A12619 | Avanafil | **** | |||||||||
| A10066 | Aminophylline | * | adenosine receptor | ||||||||
| A15799 | TAK-063 | **** | |||||||||
| A13722 | Deltarasin | *** | |||||||||
| A10541 | Luteolin | * | * | * | * | * | |||||
| A10464 | Icariin | ** | mAChR,AChR | ||||||||
| A10480 | Irsogladine | ||||||||||
| A10319 | Dipyridamole | ||||||||||
| A10339 | Dyphylline | ||||||||||
| A11527 | PF-8380 | *** | |||||||||
| A10965 | Vardenafil | *** | **** | ||||||||
| A11019 | Ibudilast (KC-404) | ||||||||||
| A11289 | Apremilast (CC 10004) | *** | |||||||||
| A11326 | Bay 60-7550 | **** | |||||||||
| A11602 | Vinpocetine | Sodium channel | |||||||||
| A12550 | Zardaverine | ** | ** | ||||||||
| A12631 | Sildenafil | *** | *** | ||||||||
| A12776 | AN2728 | *** | |||||||||
| A13121 | PF-04447943 | *** | |||||||||
| A13467 | MK-0359 | ||||||||||
| A13596 | Cilostamide | *** | |||||||||
| A15191 | Nortadalafil | ||||||||||
| A15197 | Oglemilast | **** | |||||||||
| A15198 | Olprinone Hydrochloride |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Sildenafil
Catalog No. A12631 PDE5 抑制剂Sildenafil是选择性磷酸二酯酶5（PDE5）抑制剂之一（IC50 = 5.22 nM），被认为是治疗勃起功能障碍的最佳方法。 了解更多 -
TAK-063
Catalog No. A15799 -
Olprinone Hydrochloride
Catalog No. A15198 -
Nortadalafil
Catalog No. A15191 PDE5 抑制剂Nortadalafil是去甲基他达拉非，它是一种PDE5抑制剂，目前以药丸形式销售，用于治疗勃起功能障碍（ED），名称为Cialis。并以Adcirca为名，用于治疗肺动脉高压。 了解更多 -
GSK256066 2,2,2-trifluoroacetic acid
Catalog No. A15097 PDE 抑制剂GSK256066是一种选择性PDE4B（与A-D型同等亲和力）抑制剂，IC50为3.2 pM，对PDE1/2/3/5/6的选择性> 380,000倍，对PDE4B与PDE7的选择性> 2500倍。 了解更多 -
Cilostamide
Catalog No. A13596 -
PDE-9 inhibitor
Catalog No. A11532 -
AN3199
Catalog No. A12228 -
PF-05180999
Catalog No. A13006 PDE2A inhibitorPF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. 了解更多 -
Sildenafil citrate
Catalog No. A10841 PDE5 inhibitorSildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. 了解更多 -
Mirodenafil dihydrochloride
Catalog No. A18047 PDE-5 inhibitorMirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多 -
Deltasonamide 2 (TFA)
Catalog No. A21979 PDEδ inhibitorDeltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多 -
Deltasonamide 2
Catalog No. A21970 PDEδ inhibitorDeltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多 -
ITI214 free base
Catalog No. A21947 picomolar PDE1 inhibitorITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多 -
TP-10
Catalog No. A21935 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
BAY 73-6691 racemate
Catalog No. A21745 PDE9 inhibitorBAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. 了解更多 -
Saterinone hydrochloride
Catalog No. A21402 PDE3 inhibitorSaterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. 了解更多 -
Mirodenafil
Catalog No. A21260 PDE-5 inhibitorMirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多 -
D159687
Catalog No. A21228 -
PF-04957325
Catalog No. A21246 PDE8 inhibitorPF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. 了解更多 -
Roflumilast N-oxide
Catalog No. A16984 -
Ademetionine
Catalog No. A17531 PDE4B inhibitorAdemetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. 了解更多 -
Fosphenytoin disodium
Catalog No. A18184 PDE3 inhibitorFosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. 了解更多 -
PDE12-IN-3
Catalog No. A18579 PDE12 inhibitorPDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. 了解更多 -
PF-05085727
Catalog No. A20098 PDE2A inhibitorPF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. 了解更多 -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
Cilostazol
Catalog No. A10217 -
Pimobendan (Vetmedin)
Catalog No. A10733 -
PF-2545920
Catalog No. A11191 -
Ibudilast (KC-404)
Catalog No. A11019 -
Cilomilast (SB-207499)
Catalog No. A10216 PDE-4 抑制剂Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂，具有抗炎作用。可针对与COPD相关的支气管收缩，粘液分泌过多和气道重塑。 了解更多 -
Hesperetin
Catalog No. A10449 PDE4 抑制剂Hesperetin是一种选择性磷酸二酯酶(PDE)4抑制剂，存在于中药“陈皮”中。橙皮素是一种柑橘类黄酮，据报道可以降低血浆胆固醇。橙皮素降低Hep-G2细胞中ACAT-2 mRNA的转录，并以剂量依赖的方式降低ApoB蛋白的合成。它也是类癌的潜在疗法。 了解更多
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