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￥ 0.00 PI3K / Akt / mTOR
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GDC-0941 (Pictilisib)
Catalog No. A10421 PI3K 抑制剂GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂，p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。 了解更多 -
CAL-101 (GS-1101, Idelalisib)
Catalog No. A10172 PI3K 抑制剂CAL-101 (GS-1101,Idelalisib)是PI3K的同种型选择性抑制剂，可诱导慢性淋巴细胞性白血病（CLL）细胞凋亡。 了解更多 -
BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No. A10133 PI3K/mTOR 抑制剂BEZ235 (NVP-BEZ235,Dactolisib)是通过与这些酶的ATP结合裂隙结合来抑制PI3K和mTOR激酶活性。 了解更多 -
NU-7441 (KU-57788)
Catalog No. A11098 DNA-PK 抑制剂NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。 了解更多 -
BKM120 (NVP-BKM120, Buparlisib)
Catalog No. A11016 PI3K 抑制剂?BKM120 (NVP-BKM120,Buparlisib)是生物可利用的口服泛I类磷脂酰肌醇3激酶（PI3K）激酶抑制剂，在无细胞试验中作用于p110α/β/δ/γ的。对VPS34，mTOR，DNAPK的作用效果下降，而对 PI4Kβ几乎没有活性。 了解更多 -
PF-04691502
Catalog No. A11024 PI3K/mTOR 抑制剂PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。 了解更多 -
PHT-427
Catalog No. A11032 -
Triciribine phosphate (NSC-280594)
Catalog No. A11033 AKT 抑制剂Triciribine phosphate是一种DNA synthesis抑制剂，也抑制PC3细胞系中的Akt和CEM-SS，H9，H9IIIB，U1细胞中的HIV-1，IC50分别为130 nM和20 nM；对PI3K/PDK1没有抑制作用；作用于缺乏腺苷激酶的细胞，活性降低5000 了解更多 -
A-443654
Catalog No. A11287 -
Triciribine
Catalog No. A13210 -
Akt-l-1
Catalog No. A12435 -
AT13148
Catalog No. A12464 -
Miltefosine
Catalog No. A14138 -
AT7867 2HCl
Catalog No. A15006 Akt 抑制剂AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。 了解更多 -
Tomatidine
Catalog No. A16233 -
Afuresertib
Catalog No. A16392 -
Borussertib
Catalog No. A13364 Akt inhibitorBorussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. 了解更多 -
AKT Kinase Inhibitor
Catalog No. A11285 Akt kinase inhibitorAKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity. 了解更多 -
Isobavachalcone
Catalog No. A11453 Akt inhibitorIsobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). 了解更多 -
3CAI
Catalog No. A20924 -
Solenopsin
Catalog No. A21087 ATP-competitive AKT inhibitorSolenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . 了解更多 -
Ipatasertib dihydrochloride
Catalog No. A21734 pan-Akt inhibitorIpatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多 -
AKT-IN-1
Catalog No. A21009 -
Palomid 529 (P529)
Catalog No. A10693 -
GDC-0068 (Ipatasertib, RG-7440)
Catalog No. A11246 Akt 抑制剂GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。 了解更多 -
TIC10 isomer
Catalog No. A12720 -
10-DEBC HCl
Catalog No. A13590 AKT/PKB 抑制剂?10-DEBC HCl是Akt/PKB的选择性抑制剂。它抑制IGF-1刺激的磷酸化和Akt的激活（在2.5μM时完全抑制），抑制mTOR，p70 S6激酶的下游激活。 了解更多 -
Afuresertib HCl
Catalog No. A13030 AKT 抑制剂?Afuresertib HCl，也称为GSK2110183，是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B）的生物利用抑制剂。它结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关，PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多 -
GSK2141795 (Uprosertib, GSK795)
Catalog No. A15809 Akt 抑制剂GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。 了解更多 -
SC 66
Catalog No. A12081 -
TIC10
Catalog No. A15903 -
Akt1 and Akt2-IN-1
Catalog No. A16285 AKT 1/2 抑制剂Akt1 and Akt2-IN-1是Akt1（IC50 = 3.5 nM）和Akt2（IC50 = 42 nM）的变构抑制剂，具有有效且平衡的活性。 了解更多 -
ARQ-092 (Miransertib)
Catalog No. A16286 -
AKT inhibitor VIII (AKTI-1/2)
Catalog No. A11286 AKT 抑制剂AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物，在体外激酶测定中，该化合物有效和选择性地抑制Akt1/Akt2活性（对于Akt1，Akt2和Akt3，IC50分别为58 nM，210 nM和2.12μM）。 了解更多
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