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Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.05 mL | 95.26 mL | 190.52 mL |
| 0.5 mM | 3.81 mL | 19.05 mL | 38.1 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.05 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
*The above data is based on the productmolecular weight 524.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13344 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 524.88 |
| Formula | C23H20ClF3N4O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1628287-16-0 |
| Synonyms | HC-608, HC608, HC 608, Pico-145, Pico 145 |
| SMILES | O=C1C2=C(N=C(OC3=CC=CC(OC(F)(F)F)=C3)N2CC4=CC=C(Cl)C=C4)N(C)C(N1CCCO)=O |
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