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PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.07 mL | 105.36 mL | 210.72 mL |
| 0.5 mM | 4.21 mL | 21.07 mL | 42.14 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.07 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
*The above data is based on the productmolecular weight 474.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19392 |
|---|---|
| M. Wt | 474.56 |
| Formula | C25H30N8O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1417630-95-5 |
| SMILES | COCCN1C2=C(C3=NN=C(C4=NC5=C(NCC6CCNCC6)C=CC=C5C=C4)N3N=C2)OCC1 |
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