PIM447 (LGH447)

Name: PIM447 (LGH447)
SKU: A16807
Price: 770 CNY
Rating: 5 (288 reviews)

目录号: A16807

Pim 抑制剂

PIM447 是一种新型的全谱PIM激酶抑制剂，其Ki值分别针对 PIM1、PIM2、PIM3 为6 pM、18 pM、9 pM。它还能抑制 GSK3β、PKN1 和 PKCτ，但其效力显著较低，IC50在1至5 μM之间（相对于PIMs的Ki，差异超过105倍）。

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Grouped product items
规格	价格	库存
1mg	¥770.00	现货
2mg	¥1,085.00	现货
5mg	¥1,995.00	现货
10mg	¥3,290.00	现货
25mg	¥5,320.00	现货
50mg	¥6,860.00	现货
*10mM 1mL in DMSO**	¥2,205.00	现货
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Data Sheet

SDS

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生物活性

Discription

PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16807
分子式	C24H23F3N4O
分子量	440.47
CAS号	1210608-43-7
SMILES	O=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3
其他名称	LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	76 mg/mL (159.35 mM)
	Water	Insoluble
	Ethanol	76 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.7 mL	113.52 mL	227.03 mL
0.5 mM	4.54 mL	22.7 mL	45.41 mL
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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