Piperlongumine
目录号: A14124
TrxR1/CRM1 抑制剂
Piperlongumine 选择性地杀死癌细胞,不论 p53 状态如何,而不会伤害正常细胞。它结合并抑制已知调节氧化应激的蛋白质,特别是谷胱甘肽S-转移酶 pi 1 (GSTP1)。
Discription | Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). | |||||
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Cell Research |
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目录号 | A14124 |
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分子式 | C17H19NO5 |
分子量 | 317.3 |
CAS号 | 20069-09-4 |
SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O |
其他名称 | Piplartine |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | Warmed: 15 mg/mL (47.26 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 6 mg/mL (18.9 mM) | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 31.52 mL | 157.58 mL | 315.16 mL |
0.5 mM | 6.3 mL | 31.52 mL | 63.03 mL |
1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2