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Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。
靶点信息
| Topo II | ||||
| In vitro | DMSO | 6 mg/mL (9.56 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.93 mL | 79.66 mL | 159.33 mL |
| 0.5 mM | 3.19 mL | 15.93 mL | 31.87 mL |
| 1 mM | 1.59 mL | 7.97 mL | 15.93 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.19 mL |
*The above data is based on the productmolecular weight 627.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10735 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 627.64 |
| Formula | C32H37NO12 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 72496-41-4 |
| Synonyms | THP-Adriamycin |
| SMILES | C[C@@H]1[C@@H]([C@@H](C[C@H](O1)OC2C[C@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O[C@@H]6CCCCO6 |
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