PK11007
目录号: A16833
p53 activator
PK11007 是一种针对 p53 的抗癌药物，它通过选择性烷基化两个表面暴露的半胱氨酸来稳定野生型和突变型 p53，而不影响其 DNA 结合活性。它不仅通过重新激活 p53 来发挥抗肿瘤功能，还通过其他细胞机制发挥作用，例如增加细胞 ROS 至毒性水平和激活 UPR。
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生物活性
| Discription | PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR. |
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产品信息
| 目录号 | A16833 |
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| 分子式 | C6H5ClN2O4S |
| 分子量 | 236.63 |
| CAS号 | 38275-34-2 |
| SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
| 其他名称 | PK 11007, PK-11007 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 46 mg/mL (194.39 mM) | |
| Water | 46 mg/mL (194.39 mM) | ||
| Ethanol | 23 mg/mL (97.19 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.26 mL | 211.3 mL | 422.6 mL |
| 0.5 mM | 8.45 mL | 42.26 mL | 84.52 mL |
| 1 mM | 4.23 mL | 21.13 mL | 42.26 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.45 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 PK11007 | PK11007 供应商 | PK11007 花费 | PK11007 生产商 | 订购 PK11007 | PK11007 代理商
| 购买 38275-34-2 | 38275-34-2 供应商 | 38275-34-2 花费 | 38275-34-2 生产商 | 订购 38275-34-2 | 38275-34-2 代理商