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PK11007是一种抗p53药物,可通过两个表面暴露的半胱氨酸的选择性烷基化来稳定野生型和突变型p53,而不会损害其DNA结合活性。它不仅通过重新激活p53发挥抗肿瘤功能,还通过其他细胞机制发挥作用,例如将细胞ROS升高至毒性水平并激活UPR。
In vitro | DMSO | 46 mg/mL (194.39 mM) | |
Water | 46 mg/mL (194.39 mM) | ||
Ethanol | 23 mg/mL (97.19 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 42.26 mL | 211.3 mL | 422.6 mL |
0.5 mM | 8.45 mL | 42.26 mL | 84.52 mL |
1 mM | 4.23 mL | 21.13 mL | 42.26 mL |
5 mM | 0.85 mL | 4.23 mL | 8.45 mL |
*The above data is based on the productmolecular weight 236.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A16833 |
---|---|
作用机制 | Activator (激活剂) |
M. Wt | 236.63 |
Formula | C6H5ClN2O4S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 38275-34-2 |
Synonyms | PK 11007, PK-11007 |
SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
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