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PKI-587 ( Gedatolisib )

PKI-587 ( Gedatolisib )

Name: PKI-587 ( Gedatolisib )
SKU: A11079

目录号: A11079

PI3K/mTOR 抑制剂

PKI-587 ( Gedatolisib ) Chemical Structure

CAS NO. 1197160-78-3

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 630.00
50 mg	￥ 2,520.00
100 mg	￥ 4,760.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。

靶点信息

PI3Kα (Cell-free assay)	mTOR (Cell-free assay)	PI3Kγ (Cell-free assay)
0.4 nM	1.6 nM	5.4 nM

溶解度 *

In vitro	DMSO	2 mg/mL (3.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.24 mL	81.21 mL	162.42 mL
0.5 mM	3.25 mL	16.24 mL	32.48 mL
1 mM	1.62 mL	8.12 mL	16.24 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

*The above data is based on the productmolecular weight 615.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11079
作用机制	Inhibitor (抑制剂)
M. Wt	615.7
Formula	C32H41N9O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1197160-78-3
Synonyms	PKI587, Gedatolisib
SMILES	CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6