Pleconaril

Name: Pleconaril
SKU: A20630
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A20630

capsid 抑制剂

Pleconaril 是一种曾用于治疗肠道病毒感染的衣壳抑制剂。Pleconaril 在抑制复制方面有效，其 IC50 为 50 nM。

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规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥735.00	现货
25mg	¥1,610.00	现货
50mg	¥2,695.00	现货
100mg	¥3,990.00	现货
200mg	¥5,495.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.

Cell Research

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Cell Line	Type	Value	Description	References
H1-HeLa	CC50	19.7 μM	Cytotoxicity against human H1HeLa cells assessed as reduction in cell viability after 3 days by MTT assay	[PMID: 30034598]
H1-HeLa	CC50	19.7 μM	Cytotoxicity against human H1HeLa cells assessed as decrease in cell viability after 3 days by MTT assay	[PMID: 28581749]
H1-HeLa	CC50	20.8 μM	Cytotoxicity against human H1-HeLa cells assessed as reduction in cell viability by MTT assay	[PMID: 35292344]
H1-HeLa	CC50	53.5 μM	Cytotoxicity in human H1HeLa cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 28587824]
HeLa	EC50	> 42.8 μM	Antiviral activity against human coxsackievirus B3 infected in human HeLa cells assessed as reduction in virus-induced cytopathicity incubated for 3 days by MTT assay	[PMID: 28587824]
HeLa	IC50	≤ 0.18 μM	Cytotoxicity against human HeLa cells after 3 days by MTT assay	[PMID: 31226653]
HeLa	EC50	0.13 μM	Antiviral activity against human coxsackievirus B1 infected in human HeLa cells assessed as reduction in virus-induced cytopathicity incubated for 3 days by MTT assay	[PMID: 28587824]
HeLa	EC50	0.51 μM	Antiviral activity against human poliovirus 3 infected in human HeLa cells assessed as reduction in virus-induced cytopathicity incubated for 3 days by MTT assay	[PMID: 28587824]
HeLa	EC50	1.4 μM	Antiviral activity against Human poliovirus 3 infected in human HeLa cells assessed as protection against virus induced cytopathic effect after 2 days by MTT assay	[PMID: 28581749]
HeLa	CC50	12.6 μg/mL	Cytotoxicity against human HeLa cells after 72 hrs	[PMID: 18247552]

Showing 1 to 10 of 19 entries

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产品信息

目录号	A20630
分子式	C18H18F3N3O3
分子量	381.35
CAS号	153168-05-9
SMILES	FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F
其他名称	VP 63843, VP63843, VP-63843; Win 63843, Win63843, Win-63843
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	74 mg/mL (194.05 mM)
	Water	<1 mg/mL
	Ethanol	74 mg/mL (194.05 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.22 mL	131.11 mL	262.23 mL
0.5 mM	5.24 mL	26.22 mL	52.45 mL
1 mM	2.62 mL	13.11 mL	26.22 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

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