PLX4032 (Vemurafenib)

Name: PLX4032 (Vemurafenib)
SKU: A10739
Price: 140 CNY
Rating: 5 (12 reviews)

目录号: A10739

Raf 抑制剂

12 篇发表文献

PLX4032（Vemurafenib），也被称为 RG7204、Vemurafenib、R7204；RO5185426。PLX4032 是一种 B-raf 抑制剂，其 IC50 为 44 nM。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥140.00	现货
25mg	¥315.00	现货
50mg	¥455.00	现货
100mg	¥665.00	现货
1g	¥3,500.00	现货
200mg	¥1,225.00	现货
500mg	¥2,100.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用PLX4032 (Vemurafenib)发表的12篇文献

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Lee YJ, .et al. , Research Square, 2022, April 27th

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Guixin Zhu, .et al. , Nat Cell Biol, 2021, Sep;23(9):978-991 PMID: 34497368

Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840

Kudo K, .et al. , FASEB J, 2018, Dec 3:fj201800664RR PMID: 30508500

Min Ho Choe, .et al. , Cell Death Dis, 2018, Jun; 9(6): 640 PMID: 29844307

Jan Dorrie, .et al. , Int J Mol Sci, 2018, Jan; 19(1): 289 PMID: 29346301

Aishwarya Kundu, .et al. , Mol Carcinog, 2017, Jan; 56(1): 49-61 PMID: 26878440

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Toshinori Sueda, .et al. , Sci Rep, 2016, 6: 18949 PMID: 26750638

Yanling Li, .et al. , Onco Targets Ther, 2015, 8: 1043-1051 PMID: 25999739

生物活性

Discription

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10739
分子式	C23H18ClF2N3O3S
分子量	489.9
CAS号	918504-65-1
SMILES	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
其他名称	RG7204,RO5185426,Zelboraf
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	83 mg/mL (169.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O (suspension)	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.41 mL	102.06 mL	204.12 mL
0.5 mM	4.08 mL	20.41 mL	40.82 mL
1 mM	2.04 mL	10.21 mL	20.41 mL
5 mM	0.41 mL	2.04 mL	4.08 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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