PLX51107

Name: PLX51107
SKU: A18345
Price: 315 CNY
Rating: 5 (288 reviews)

目录号: A18345

selective BET inhibitor

PLX51107 是一种强效且选择性的 BET 抑制剂，其对 BRD2、BRD3、BRD4 和 BRDT 的 BD1 的 Kd 值分别为 1.6、2.1、1.7 和 5 nM，对 BD2 的 Kd 值分别为 5.9、6.2、6.1 和 120 nM；PLX51107 还与 CBP 和 EP300 的 溴结构域 产生相互作用（Kd 在 100 nM 范围内）。

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Grouped product items
规格	价格	库存
1mg	¥315.00	现货
2mg	¥455.00	现货
5mg	¥805.00	现货
10mg	¥1,330.00	现货
25mg	¥2,380.00	现货
50mg	¥3,570.00	现货
100mg	¥5,180.00	现货
*10mM 1mL in DMSO**	¥875.00	现货
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Data Sheet

SDS

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生物活性

Discription	PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range).

产品信息

目录号	A18345
分子式	C26H22N4O3
分子量	438.487
CAS号	1627929-55-8
SMILES	C[C@@H](C1=NC=CC=C1)N2C=C(C3=CC=C(C(O)=O)C=C3)C4=NC=C(C5=C(C)ON=C5C)C=C42
其他名称	PLX-51107, PLX 51107
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	84 mg/mL (191.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.81 mL	114.03 mL	228.06 mL
0.5 mM	4.56 mL	22.81 mL	45.61 mL
1 mM	2.28 mL	11.4 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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