PLX8394
目录号: A16840
BRAF inhibitor
PLX8394 是一种新一代、口服、小分子 BRAF 抑制剂，其 IC50 值分别针对 BRAF(V600E)、WT BRAF 和 CRAF 为 3.8 nM、14 nM 和 23 nM。它具有潜在的抗肿瘤活性。
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生物活性
| Discription | PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity. |
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产品信息
| 目录号 | A16840 |
|---|---|
| 分子式 | C25H21F3N6O3S |
| 分子量 | 542.53 |
| CAS号 | 1393466-87-9 |
| SMILES | O=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O |
| 其他名称 | PLX 8394, PLX-8394 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 96 mg/mL (176.95 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.43 mL | 92.16 mL | 184.32 mL |
| 0.5 mM | 3.69 mL | 18.43 mL | 36.86 mL |
| 1 mM | 1.84 mL | 9.22 mL | 18.43 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 PLX8394 | PLX8394 供应商 | PLX8394 花费 | PLX8394 生产商 | 订购 PLX8394 | PLX8394 代理商
| 购买 1393466-87-9 | 1393466-87-9 供应商 | 1393466-87-9 花费 | 1393466-87-9 生产商 | 订购 1393466-87-9 | 1393466-87-9 代理商