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PNU 282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ?? 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.77 mL | 188.86 mL | 377.71 mL |
| 0.5 mM | 7.55 mL | 37.77 mL | 75.54 mL |
| 1 mM | 3.78 mL | 18.89 mL | 37.77 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.55 mL |
*The above data is based on the productmolecular weight 264.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22518 |
|---|---|
| M. Wt | 264.75 |
| Formula | C14H17ClN2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 711085-63-1 |
| Synonyms | PNU-282987, PNU 282987, PNU282987. |
| SMILES | O=C(N[C@H]1CN2CCC1CC2)C3=CC=C(Cl)C=C3 |
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