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Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 52.01 mL | 260.06 mL | 520.13 mL |
| 0.5 mM | 10.4 mL | 52.01 mL | 104.03 mL |
| 1 mM | 5.2 mL | 26.01 mL | 52.01 mL |
| 5 mM | 1.04 mL | 5.2 mL | 10.4 mL |
*The above data is based on the productmolecular weight 192.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21318 |
|---|---|
| M. Wt | 192.26 |
| Formula | C11H16N2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 161417-03-4 |
| Synonyms | ABT-089 |
| SMILES | CC1=C(OC[C@H]2NCCC2)C=CC=N1 |
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