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PRI-724是ICG-001的异构体或对映异构体，是一种强力的特异性抑制剂癌症干细胞中的Wnt信号通路具有潜在的抗肿瘤活性。
靶点信息
| Wnt/β-catenin | ||||
| 150 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.24 mL | 91.2 mL | 182.4 mL |
| 0.5 mM | 3.65 mL | 18.24 mL | 36.48 mL |
| 1 mM | 1.82 mL | 9.12 mL | 18.24 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.65 mL |
*The above data is based on the productmolecular weight 548.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15856 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 548.24 |
| Formula | C33H32N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 847591-62-2 |
| Synonyms | PRI 724, PRI724 |
| SMILES | O=C(N(CC1)[C@](CN(CC2=C3C=CC=CC3=CC=C2)C([C@@H]4CC5=CC=C(O)C=C5)=O)([H])N4C1=O)NCC6=CC=CC=C6 |
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