PRKAR1A

Catalog No.: AP4567

产品概述

cAMP-Dependent Protein Kinase A regulatory subunit I a Recombinant

Product Details

cAMP-dependent PKA is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions. The recombinant PKA regulatory subunit I a is a dimeric 90kDa protein.

库存: 现货

规格 价格 数量
PRKAR1A 1µg
¥ 770.00
PRKAR1A 3µg
¥ 2,030.00
PRKAR1A 100µg
¥ 56,980.00

详情

cAMP-Dependent Protein Kinase A regulatory subunit I a Recombinant
目录号 AP4567
Formulation PKA regulatory subunit I a is supplied in 50% glycerol.
Uniprot ACC# P10644
Purity Greater than 90% as determined by SDS-PAGE.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Source Escherichia Coli.
Synonyms cAMP-dependent protein kinase type I-alpha regulatory subunit, Tissue-specific extinguisher 1, TSE1, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, PRKAR1A, MGC17251, DKFZp779L0468.
Transportation method Shipped with Ice Packs

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