PRN1371
目录号: A19340
FGFR1-4/CSF1R inhibitor
PRN1371 是一种高度选择性和强效的 FGFR1-4 和 CSF1R 抑制剂,其半抑制浓度(IC50)分别为 FGFR1 0.6 nM、FGFR2 1.3 nM、FGFR3 4.1 nM、FGFR4 19.3 nM 和 CSF1R 8.1 nM。
Discription | PRN1371 is a highly selective and potent FGFR1-4 and CSF1R inhibitor with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R, respectively. | |||||
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Targets |
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Cell Research |
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目录号 | A19340 |
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分子式 | C26H30Cl2N6O4 |
分子量 | 561.46 |
CAS号 | 1802929-43-6 |
SMILES | O=C1C(C2=C(Cl)C(OC)=CC(OC)=C2Cl)=CC3=CN=C(NC)N=C3N1CCCN4CCN(C(C=C)=O)CC4 |
其他名称 | PRN 1371, PRN-1371 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 95 mg/mL (169.2 mM) | |
Water | Insoluble | ||
Ethanol | 6 mg/mL (10.68 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 17.81 mL | 89.05 mL | 178.11 mL |
0.5 mM | 3.56 mL | 17.81 mL | 35.62 mL |
1 mM | 1.78 mL | 8.91 mL | 17.81 mL |
5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2