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PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.97 mL | 64.86 mL | 129.73 mL |
| 0.5 mM | 2.59 mL | 12.97 mL | 25.95 mL |
| 1 mM | 1.3 mL | 6.49 mL | 12.97 mL |
| 5 mM | 0.26 mL | 1.3 mL | 2.59 mL |
*The above data is based on the productmolecular weight 770.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18785 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 770.84 |
| Formula | C41H42N10O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2093388-33-9 |
| SMILES | O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NCCCC7=CC=CC8=C7CN(C(CC9)C(NC9=O)=O)C8=O |
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