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￥ 0.00 Proteases
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BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
Compound E
Catalog No. A21292 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase 抑制剂BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
LY2811376
Catalog No. A11776 -
BMS 433796
Catalog No. A11337 -
E 2012
Catalog No. A11393 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
Flurizan
Catalog No. A12433 -
LY3039478
Catalog No. A13544 -
IMR-1A
Catalog No. A16223 -
Epoxomicin
Catalog No. A12730 -
Proteasome-IN-1
Catalog No. A12254 proteasome inhibitorProteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1. 了解更多 -
Ixazomib citrate
Catalog No. A18017 20S proteasome inhibitorIxazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM. 了解更多 -
(R)-MG-132
Catalog No. A21980 proteasome inhibitor(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132. 了解更多 -
MLN9708
Catalog No. A10602 -
Bortezomib (Velcade)
Catalog No. A10160 Proteasome 抑制剂Bortezomib (Velcade)是26S蛋白酶体的高度选择性，可逆抑制剂。 了解更多 -
MLN2238 (Ixazomib)
Catalog No. A10600 Proteasome 抑制剂MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点，IC50值为3.4 nM。 了解更多 -
CEP-18770 (Delanzomib)
Catalog No. A11145 Proteasome 抑制剂CEP-18770 (Delanzomib)是一种新型口服活性蛋白酶体抑制剂，IC50为3.8 nM，具有良好的肿瘤选择性，可用于治疗对蛋白酶体抑制有反应的MM和其他恶性肿瘤。 了解更多 -
PR-171 (Carfilzomib)
Catalog No. A11278 Proteasome 抑制剂PR-171 (Carfilzomib)是四肽环氧酮和选择性蛋白酶体抑制剂。它是环氧霉素的类似物。 了解更多 -
Lactacystin
Catalog No. A12768 -
Gliotoxin
Catalog No. A13711 -
ONX 0912 (Oprozomib)
Catalog No. A14181 Proteasome 抑制剂ONX 0912 (Oprozomib)是一种三肽环氧酮，可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。 了解更多 -
PI-1840
Catalog No. A14146 -
Marizomib (NPI-0052, salinosporamide A)
Catalog No. A13853 Proteasome 抑制剂Marizomib (NPI-0052,salinosporamide A)是一种天然存在的salinosporamide，从海洋放线菌Salinospora tropica中分离出来，具有潜在的抗肿瘤活性。 了解更多 -
Aclacinomycin A
Catalog No. A14910 -
Dihydroeponemycin
Catalog No. A14932
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