Protein Tyrosine Phosphatase
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PTP1B inhibitor
DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property.
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PTP1B inhibitor
PTP1B-IN-8 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1.
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PTP1B inhibitor
PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively.
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PTP1B inhibitor
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
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PTP1B inhibitor
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
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PTEN 抑制剂
SF1670是选择性PTEN抑制剂(IC50 = 2 uM)。由于PTEN-mTOR通路对于控制皮质脊髓神经元的再生能力至关重要,因此PTEN缺失或其抑制剂可增强成年皮质脊髓神经元的再生能力。在临床相关的小鼠模型中,用SF1670进行预处理可增强粒细胞输注的功效。
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PTEN 抑制剂
Shikonin一种中草药成分,抑制趋化因子受体功能,抑制人类免疫缺陷病毒1型。
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- Yang J, .et al. Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress, Biomed Pharmacother, 2017, Sep;93:1343-1357 PMID: 28753907
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Bakuchiol是蛋白酪氨酸磷酸酶1B(PTP1B)的抗氧化剂。
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PTP 抑制剂
BVT 948是一种非竞争性PTP(蛋白酪氨酸磷酸酶)抑制剂。
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PTP1B 抑制剂
TCS 401是蛋白酪氨酸磷酸酶1B(PTP1B)的选择性抑制剂(对于PTP1B,CD45 D1D2,PTPβ,PTPεD1,SHP-1,Ki值为0.29、59、560、1100,> 2000,> 2000和> 2000μM,分别为PTPαD1和LAR D1D2)。
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