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Pomalidomide-PEG4-C-COOH
Catalog No. A13213 PROTAC linkerPomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. 了解更多 -
cIAP1 Ligand-Linker Conjugates 5
Catalog No. A18991 PROTAC linkercIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs. 了解更多 -
VH032-PEG5-C6-Cl
Catalog No. A12884 small molecule HaloPROTACVH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. 了解更多 -
cIAP1 Ligand-Linker Conjugates 12
Catalog No. A18998 PROTAC linkercIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 2
Catalog No. A19004 PROTAC linkercIAP1 Ligand-Linker Conjugates 2 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 can be used to design SNIPERs. 了解更多 -
NH2-PEG3-C1-Boc
Catalog No. A19084 PROTAC linkerNH2-PEG3-C1-Boc (PROTAC Linker 5) is a PROTAC linker, which refers to the PEG composition. NH2-PEG3-C1-Boc can be used in the synthesis of a series of PROTACs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 14
Catalog No. A19010 PROTAC linkercIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs. 了解更多 -
Tos-PEG3-O-C1-CH3COO
Catalog No. A19077 PROTAC linkerTos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PROTAC linker, which refers to the PEGs composition. 了解更多 -
Tos-PEG4-NH-Boc
Catalog No. A19070 PROTAC linkerTos-PEG4-NH-Boc (PROTAC Linker 7) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-NH-Boc can be used in the synthesis of a series of PROTACs. 了解更多 -
PEG3-O-CH2COOH
Catalog No. A19063 PROTAC linkerPEG3-O-CH2COOH (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. 了解更多 -
Tos-PEG3-NH-Boc
Catalog No. A19057 PROTAC linkerTos-PEG3-NH-Boc (PROTAC Linker 9) is a PROTAC linker, which refers to the PEG composition. Tos-PEG3-NH-Boc can be used in the synthesis of a series of PROTACs. 了解更多 -
Dox-Ph-PEG1-Cl
Catalog No. A18413 PROTAC linkerDox-Ph-PEG1-Cl (PROTAC Linker 34) is a PROTAC linker, which refers to the PEG composition. Dox-Ph-PEG1-Cl can be used in the synthesis of a series of PROTACs. 了解更多 -
Boc-NH-C6-amido-C4-acid
Catalog No. A18421 PROTAC linkerBoc-NH-C6-amido-C4-acid is a PROTAC linker, which refers to the alkyl/ether composition. Boc-NH-C6-amido-C4-acid can be used in the synthesis of a series of PROTACs. 了解更多 -
Bis-PEG4-acid
Catalog No. A19036 -
NH2-Ph-C4-acid-NH2-Me
Catalog No. A18436 PROTAC linkerNH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is a PROTAC linker, which refers to the Alkyl-Chain composition. NH2-Ph-C4-acid-NH2-Me can be used in the synthesis of a series of PROTACs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 11
Catalog No. A19022 PROTAC linkercIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 15
Catalog No. A19016 PROTAC linkercIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs. 了解更多 -
Cl-C6-PEG4-O-CH2COOH
Catalog No. A12719 PROTAC linkerCl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). 了解更多 -
Bis-PEG1-C-PEG1-CH2COOH
Catalog No. A18848 PROTAC linkerBis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PROTAC linker, which refers to the PEG composition. Bis-PEG1-C-PEG1-CH2COOH can be used in the synthesis of a series of PROTACs. 了解更多 -
Bis-NH2-C1-PEG3
Catalog No. A18870 PROTAC linkerBis-NH2-C1-PEG3 (PROTAC Linker 24) is a PROTAC linker, which refers to the alkyl/ether composition. Bis-NH2-C1-PEG3 can be used in the synthesis of a series of PROTACs. 了解更多 -
NH2-C2-NH-Boc
Catalog No. A12192 PROTAC linkerNH2-C2-NH-Boc (PROTAC Linker 22) is a PROTAC linker, which refers to the alkyl chain composition.NH2-C2-NH-Boc can be used in the synthesis of a series of PROTACs. 了解更多 -
Phenol-amido-C1-PEG3-N3
Catalog No. A18931 PROTAC linkerPhenol-amido-C1-PEG3-N3 (PROTAC Linker 21) is a PROTAC linker, which refers to the PEG composition. Phenol-amido-C1-PEG3-N3 can be used in the synthesis of a series of PROTACs. 了解更多 -
N3-PEG4-C2-NH2
Catalog No. A18938 PROTAC linkerN3-PEG4-C2-NH2 (PROTAC Linker 20) is a polyethylene glycol (PEG)-based PROTAC linker. N3-PEG4-C2-NH2 can be used in the synthesis of a series of PROTACs. 了解更多 -
Bis-NH2-PEG2
Catalog No. A18944 PROTAC linkerBis-NH2-PEG2 (PROTAC Linker 19) is a PROTAC linker, which refers to the PEG composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 1
Catalog No. A18978 PROTAC linkercIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs. 了解更多 -
Boc-NH-PEG2-C2-amido-C4-acid
Catalog No. A18425 PROTAC linkerBoc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PROTAC linker, which refers to the PEG composition. Boc-NH-PEG2-C2-amido-C4-acid can be used in the synthesis of a series of PROTACs. 了解更多 -
PEG6-(CH2CO2H)2
Catalog No. A18422 PEG PROTAC linkerPEG6-(CH2CO2H)2 is a PEG derivative containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. 了解更多 -
cIAP1 Ligand-Linker Conjugates 3
Catalog No. A18985 PROTAC linkercIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs. 了解更多 -
PROTAC ERRα ligand 2
Catalog No. A18939 ERRα inverse agonistPROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多 -
PROTAC ERRα Degrader-1
Catalog No. A18910 ERRα DegraderPROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多 -
PROTAC ERRα Degrader-2
Catalog No. A18904 ERRa degraderPROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多 -
PROTAC CRBN Degrader-1
Catalog No. A18863 CRBN degraderPROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. 了解更多 -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多 -
PROTAC FLT-3 degrader 1
Catalog No. A18682 FLT-3 ITD degraderPROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. 了解更多 -
PROTAC Sirt2 Degrader-1
Catalog No. A20005 Sirt2 degraderPROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多 -
PROTAC Mcl1 degrader-1
Catalog No. A18373 Mcl-1 inhibitorPROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. 了解更多 -
PROTAC Bcl2 degrader-1
Catalog No. A18355 degraderPROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. 了解更多 -
Gefitinib-based PROTAC 3
Catalog No. A19093 Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. 了解更多 -
THAL-SNS-032
Catalog No. A19088 CDK9 degrader PROTACTHAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
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