PROTACs

产品 51 到 79 共 79个

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  1. FKBP12 PROTAC dTAG-7

    Catalog No. A19081
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    heterobifunctional degrader
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. 了解更多
  2. PROTAC BET degrader-2

    Catalog No. A18785
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    PROTAC BET degrader
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. 了解更多
  3. dBET1

    Catalog No. A16858
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    BRD4 protein degrader
    dBET1是基于PROTAC技术的有效BRD4蛋白降解剂,EC50为430 nM。 了解更多
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    MZ1

    Catalog No. A17014
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    BRD4 protein degrader
    MZ1是BRD2和BRD3上BRD4可逆,持久和选择性去除的有效诱导剂。 了解更多
  4. dBET57

    Catalog No. A19133
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    BRD4BD1degrader
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. 了解更多
  5. MZP-55

    Catalog No. A19415
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    BRD3/4 degrader
    MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. 了解更多
  6. MZP-54

    Catalog No. A19426
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    BRD3/4 degrader
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. 了解更多
  7. VH032-cyclopropane-F

    Catalog No. A18417
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    VH032-based VHL ligand
    VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). 了解更多
  8. Thalidomide fluoride

    Catalog No. A12144
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    Thalidomide-based Cereblon ligand
    Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966). 了解更多
  9. BC-1215

    Catalog No. A18605
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    FBXO3 inhibitor
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. 了解更多
  10. TD-106

    Catalog No. A18595
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    CRBN modulator
    TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation. 了解更多
  11. E3 ligase Ligand 14

    Catalog No. A19028
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. 了解更多
  12. E3 ligase Ligand 10

    Catalog No. A19045
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. 了解更多
  13. E3 ligase Ligand 9

    Catalog No. A19051
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. 了解更多
  14. Thalidomide-O-amido-C3-NH2 (TFA)

    Catalog No. A21801
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多
  15. cIAP1 Ligand-Linker Conjugates 15 hydrochloride

    Catalog No. A21758
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    E3 ligase ligand-linker conjugate
    cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs. 了解更多
  16. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

    Catalog No. A21753
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    E3 ligase ligand-linker conjugate
    cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs. 了解更多
  17. Lenalidomide-C5-NH2

    Catalog No. A18414
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    Lenalidomide-based Cereblon ligand
    Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs. 了解更多
  18. Pomalidomide-PEG4-Ph-NH2

    Catalog No. A12066
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    E3 ligase ligand-linker conjugate
    Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. 了解更多
  19. CCK2R Ligand-Linker Conjugates 1

    Catalog No. A18411
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    ligand-linker conjugate
    CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker. 了解更多
  20. Thalidomide-O-amido-PEG2-C2-NH2 (TFA)

    Catalog No. A21634
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. 了解更多
  21. Thalidomide-O-amido-C6-NH2 (TFA)

    Catalog No. A21639
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多
  22. (S,R,S)-AHPC-PEG3-NH2

    Catalog No. A21660
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. 了解更多
  23. (S,R,S)-AHPC-PEG2-NH2

    Catalog No. A21665
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. 了解更多
  24. (S,R,S)-AHPC-PEG4-NH2

    Catalog No. A21671
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. 了解更多
  25. Pomalidomide-C2-NH2

    Catalog No. A18855
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology. 了解更多
  26. Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

    Catalog No. A18842
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多
  27. Pomalidomide-C2-NH2 hydrochloride

    Catalog No. A21768
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多
  28. (S,R,S)-AHPC-C3-NH2

    Catalog No. A18818
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology. 了解更多

产品 51 到 79 共 79个

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