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PS-1145是一种高度特异性的IKB激酶（IKK）抑制剂，可有效抑制PC细胞的基础和诱导型NF-kB活性。
靶点信息
| IKK | ||||
| 88 nM |
| In vitro | DMSO | 61 mg/mL (189 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 2 mg/mL (6.19 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.98 mL | 154.92 mL | 309.84 mL |
| 0.5 mM | 6.2 mL | 30.98 mL | 61.97 mL |
| 1 mM | 3.1 mL | 15.49 mL | 30.98 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
*The above data is based on the productmolecular weight 322.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12789 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 322.75 |
| Formula | C17H11ClN4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 431898-65-6 |
| Synonyms | PS1145,PS 1145 |
| SMILES | C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4 |
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