PSI-7977

Name: PSI-7977
SKU: A11529

目录号: A11529

HCV Nucleotide 抑制剂

Product Citations (1)

PSI-7977 Chemical Structure

CAS NO. 1190307-88-0

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。

库存：现货

规格	价格	数量
5 mg	￥ 315.00
10 mg	￥ 455.00
25 mg	￥ 840.00
10mM * 1mL in DMSO	￥ 560.00

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产品详情

生物活性

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。

靶点信息

NS5B polymerase

溶解度 *

In vitro	DMSO	Warmed: 86 mg/mL (162.43 mM)
	Water	Warmed: 9 mg/mL (16.99 mM)
	Ethanol	86 mg/mL (162.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.89 mL	94.44 mL	188.88 mL
0.5 mM	3.78 mL	18.89 mL	37.78 mL
1 mM	1.89 mL	9.44 mL	18.89 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11529
作用机制	Inhibitor (抑制剂)
M. Wt	529.45
Formula	C22H29FN3O9P
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1190307-88-0
Synonyms	Sofosbuvir, PSI7977, GI-7977
SMILES	C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3