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PZ-2891

PZ-2891

Name: PZ-2891
SKU: A18880

目录号: A18880

PANK modulator

PZ-2891 Chemical Structure

CAS NO. 2170608-82-7

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 980.00
50 mg	￥ 2,800.00
100 mg	￥ 4,760.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	67 mg/mL (191.73 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.09 mL	286.18 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

*The above data is based on the productmolecular weight 349.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18880
作用机制	Modulator (调节剂)
M. Wt	349.43
Formula	C20H23N5O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2170608-82-7
Synonyms	PZ2891, PZ-2891
SMILES	N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1