PZ-2891

Name: PZ-2891
SKU: A18880
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A18880

PANK modulator

PZ-2891 是一种口服生物可利用、能穿透大脑的泛酸激酶（PANK）调节剂。在高浓度下，PZ-2891 作为正交抑制剂，而在较低的未饱和浓度下作为变构激活剂。PZ-2891 抑制人类泛酸激酶 PANK1β、PANK2 和 PANK3，其 IC50 分别为 40.2 nM、0.7 nM 和 1.3 nM。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥525.00	现货
10mg	¥805.00	现货
25mg	¥1,505.00	现货
50mg	¥2,520.00	现货
100mg	¥3,780.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription	PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

产品信息

目录号	A18880
分子式	C20H23N5O
分子量	349.43
CAS号	2170608-82-7
SMILES	N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1
其他名称	PZ2891, PZ-2891
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	67 mg/mL (191.73 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.09 mL	286.18 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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