Quarfloxin (CX-3543)

Name: Quarfloxin (CX-3543)
SKU: A12380
Price: 805 CNY
Rating: 5 (6 reviews)

目录号: A12380

rRNA biogenesis inhibitor

6 篇发表文献

Quarfloxin (CX-3543) 是一种氟喹诺酮衍生物，具有抗肿瘤活性。Quarfloxin 干扰核仁蛋白与核糖体DNA (rDNA) 模板中的G-四联体DNA结构之间的相互作用，这种相互作用对于rRNA生物合成至关重要，而在癌细胞中这种相互作用通常表达过量；干扰这种G-四联体DNA:蛋白质相互作用可能导致异常的rRNA生物合成，从而抑制核糖体合成和肿瘤细胞的凋亡。

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Grouped product items
规格	价格	库存
1mg	¥805.00	现货
5mg	¥1,225.00	现货
10mg	¥2,135.00	现货
25mg	¥3,465.00	现货
50mg	¥4,515.00	现货
100mg	¥6,195.00	现货
*10mM 1mL in DMSO**	¥1,960.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Quarfloxin (CX-3543)发表的6篇文献

Jing-Wei Liang, .et al. , Antioxidants (Basel), 2023, Dec 20;13(1):11 PMID: 38275631

Maria Razzaq, .et al. , Arch Pharm Res, 2023, Jul;46(7):598-615 PMID: 37563335

Janne J. M. van Schie, .et al. , Nat Commun, 2020, 11: 4287 PMID: 32855419

Yue Sheng, .et al. , Blood, 2020, Aug 21 PMID: 32822452

Hald øH, .et al. , Oncogene, 2018, Dec 12 PMID: 30542116

Louise E. Kerry, .et al. , PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991

生物活性

Discription

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

产品信息

目录号	A12380
分子式	C35H33FN6O3
分子量	604.67
CAS号	865311-47-3
SMILES	CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
其他名称	CX 3543; Quarfloxacin; CX3543; CX-3543
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 18 mg/mL (35.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+dd H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.54 mL	82.69 mL	165.38 mL
0.5 mM	3.31 mL	16.54 mL	33.08 mL
1 mM	1.65 mL	8.27 mL	16.54 mL
5 mM	0.33 mL	1.65 mL	3.31 mL

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