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Quercetin (Sophoretin)抑制许多酶系统，包括酪氨酸蛋白激酶，磷脂酶A2，磷酸二酯酶，线粒体ATPase，PI 3-激酶和蛋白激酶C。
Targets
| Target | Value | |
|---|---|---|
| Sirtuin | ||
| Src | ||
| PKC | ||
| PI3Kγ | IC50: 2.4μM | |
| PI3Kδ | IC50: 3.0μM | |
| PI3Kβ | IC50: 5.4μM |
| In vitro (25°C) | DMSO | 56 mg/mL (185.28 mM) | |
| Water | Insoluble | ||
| Ethanol | 9 mg/mL (29.77 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.09 mL | 165.45 mL | 330.91 mL |
| 0.5 mM | 6.62 mL | 33.09 mL | 66.18 mL |
| 1 mM | 3.31 mL | 16.55 mL | 33.09 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.62 mL |
*The above data is based on the productmolecular weight 302.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10766 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 302.2 |
| Formula | C15H10O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 117-39-5 |
| Synonyms | Sophoretin, Meletin, Quercetine |
| SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O |
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