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RAF709是B/C RAF激酶的有效抑制剂，对B-RAF和C-RAF的IC50值几乎相等，为0.4 nM。它具有高选择性，在浓度为1 μM时，对BRAF, BRAFV600E和CRAF的靶向结合率大于99%，而对DDR1、DDR2、FRK和FDGFRβ的脱靶效应非常少。
| In vitro | DMSO | 86 mg/mL (158.51 mM) | |
| Water | Insoluble | ||
| Ethanol | 86 mg/mL (158.51 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.43 mL | 92.16 mL | 184.31 mL |
| 0.5 mM | 3.69 mL | 18.43 mL | 36.86 mL |
| 1 mM | 1.84 mL | 9.22 mL | 18.43 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
*The above data is based on the productmolecular weight 542.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16842 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 542.55 |
| Formula | C28H29F3N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1628838-42-5 |
| Synonyms | RAF 709, RAF-709 |
| SMILES | O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC(C(F)(F)F)=CC=C5 |
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