Rapamycin (Sirolimus)

Name: Rapamycin (Sirolimus)
SKU: A10782

目录号: A10782

mTOR 抑制剂

Product Citations (9)

Rapamycin (Sirolimus) Chemical Structure

CAS NO. 53123-88-9

Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2（IL-2）的反应来防止其活化。

库存：现货

规格	价格	数量
5 mg	￥ 280.00
50 mg	￥ 385.00
100 mg	￥ 490.00
10mM * 1mL in DMSO	￥ 350.00

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生物活性

Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2（IL-2）的反应来防止其活化。

靶点信息

mTOR (HEK293 cells)
~0.1 nM

溶解度 *

In vitro (25°C)	DMSO	18 mg/mL (19.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.94 mL	54.69 mL	109.39 mL
0.5 mM	2.19 mL	10.94 mL	21.88 mL
1 mM	1.09 mL	5.47 mL	10.94 mL
5 mM	0.22 mL	1.09 mL	2.19 mL

*The above data is based on the productmolecular weight 914.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10782
作用机制	Inhibitor (抑制剂)
M. Wt	914.2
Formula	C51H79NO13
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	53123-88-9
Synonyms	Rapamune
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC