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￥ 0.00 Protein Tyrosine Kinases
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CHMFL-KIT-033
Catalog No. A18476 c-KIT T670I mutant inhibitorCHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM. 了解更多 -
c-Kit-IN-2
Catalog No. A18440 c-KIT inhibitorc-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively. 了解更多 -
CHMFL-ABL/KIT-155
Catalog No. A12421 ABL/c-KIT dual kinase inhibitorCHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor. 了解更多 -
Quercetin (Sophoretin)
Catalog No. A10766 MAO-B 抑制剂Quercetin (Sophoretin)抑制许多酶系统，包括酪氨酸蛋白激酶，磷脂酶A2，磷酸二酯酶，线粒体ATPase，PI 3-激酶和蛋白激酶C。 了解更多 -
1-NA-PP1
Catalog No. A13232 -
CGP77675
Catalog No. A13821 -
TC-S 7003 (Lck Inhibitor)
Catalog No. A15140 -
Lck inhibitor 2
Catalog No. A15141 Lck 抑制剂Lck inhibitor 2 是酪氨酸激酶的双苯胺基嘧啶抑制剂，包括LCK，BTK，LYN，SYK和TXK。Lck，Btk，Lyn，Btk和Txk的IC50值分别为13nM，9nM，3nM，26nM和2nM。 了解更多 -
Tilfrinib
Catalog No. A16086 -
Lyn-IN-1
Catalog No. A16265 -
KIN001-051
Catalog No. A16923 Lck 抑制剂KIN001-051是一种有效的、选择性的Lck抑制剂。淋巴细胞特异性蛋白酪氨酸激酶（Lck）是非受体蛋白酪氨酸激酶Src家族的成员，在触发细胞因子产生的T细胞受体信号转导的初始步骤中起着至关重要的作用。 了解更多 -
PD-166285
Catalog No. A13868 -
Dasatinib hydrochloride
Catalog No. A15060 Src 抑制剂Dasatinib hydrochloride是一种有效的Abl/Src双重抑制剂，IC50分别<1 nM/0.8 nM。还可以抑制c-Kit（WT/c-Kit（D816V），IC50为79 nM/37 nM。有效，选择性Raf激酶抑制剂能够抑制野生型B-Raf，B-RafV600E和c -Raf的IC50值分别为3.2、0.8和5.0 nM。 了解更多 -
KX2-391 2HCl
Catalog No. A11471 Src 抑制剂Tirbanibulin dihydrochloride是首个靶向Src肽底物位点的临床Src抑制剂(拟肽类),在癌细胞系中GI50为9-60 nM。 了解更多 -
AZM475271
Catalog No. A16241 -
T338C Src-IN-1
Catalog No. A16243 Src 抑制剂T338C Src-IN-1是有效的Src T338C突变体抑制剂。相对于WT c-Src（增加10倍），T338C（IC50 = 111 nM）的抑制作用最强。 了解更多 -
T338C Src-IN-2
Catalog No. A16244 Src 抑制剂T338C Src-IN-2是有效的突变c-Src T338C激酶抑制剂，IC50为317 nM；它还抑制T338C/V323A和T338C/V323S，IC50为57 nM/19 nM。 了解更多 -
Bosutinib (SKI-606)
Catalog No. A10161 -
NVP-BHG712
Catalog No. A10661 EphB4 抑制剂NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。 了解更多 -
Saracatinib (AZD0530)
Catalog No. A10108 Src/Abl 抑制剂Saracatinib (AZD0530)是一种高选择性，双特异性Src/Abl激酶抑制剂，对c-Src和Abl激酶的IC50分别为2.7和30 nM。 了解更多 -
Dasatinib (BMS-354825)
Catalog No. A10290 Abl-Src 抑制剂Dasatinib (BMS-354825)是一种口服多BCR/ABL和Src家族酪氨酸激酶抑制剂。Dasatinib (BMS-354825)的主要靶标是BCR/ABL，Src，c-Kit，ephrin受体和其他几种酪氨酸激酶，但不是erbB激酶，例如EGFR或Her2。 了解更多 -
ASP3026
Catalog No. A11773 -
ALK-IN-1 (Brigatinib analog, AP26113 analog)
Catalog No. A11948 ALK 抑制剂AP26113是一种有效的，选择性的ALK抑制剂，对野生型的功效为0.62 nM，对包括crizotinib耐药的L1196M系在内的多种突变体的活性也很强。在一组EML4-ALK或NPM-ALK阳性细胞系中，AP26113的IC50值为4-31 nM。 了解更多 -
CEP-28122
Catalog No. A13744 -
Brigatinib (AP26113)
Catalog No. A13450 ALK 抑制剂Brigatinib (AP26113)是一种有效的选择性ALK（IC50，0.6 nM）和ROS1（IC50，0.9 nM）抑制剂。它还以较低的效力抑制ROS1，FLT3和FLT3（D835Y）和EGFR的突变体。 了解更多 -
PF-06463922
Catalog No. A14207 ALK 抑制剂PF-06463922是一种有效的双重ALK/ROS1抑制剂，对ROS1，ALK（WT）和ALK（L1196M）的Ki分别为<0.02 nM，<0.07 nM和0.7 nM。 了解更多 -
LDK378 (Ceritinib) dihydrochloride
Catalog No. A15142 ALK 抑制剂LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。 了解更多 -
Entrectinib
Catalog No. A15801 TRK, ROS1, ALK 抑制剂Entrectinib，也称为RXDX-101和NMS-E628，是TrkA，TrkB和TrkC以及ROS1和ALK的小分子抑制剂，具有很高的效力和选择性。 了解更多 -
Crizotinib hydrochloride
Catalog No. A16245 c-Met/NPM-ALK 抑制剂Crizotinib hydrochloride是c-Met激酶和NPM-ALK的抑制剂。 了解更多
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