Regorafenib (BAY 73-4506)

Name: Regorafenib (BAY 73-4506)
SKU: A10250
Price: 175 CNY
Rating: 5 (10 reviews)

目录号: A10250

VEGFR 抑制剂

10 篇发表文献

Regorafenib（BAY 73-4506）是一种多激酶抑制剂，其IC50分别为17、40和69 nM的c-KIT、VEGFR2、B-Raf。Regorafenib（BAY 73-4506）是一种口服生物可用的多激酶抑制剂，针对肿瘤及其血管系统。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥280.00	现货
25mg	¥315.00	现货
50mg	¥595.00	现货
100mg	¥875.00	现货
200mg	¥1,330.00	现货
500mg	¥2,240.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Regorafenib (BAY 73-4506)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Regorafenib (BAY 73-4506)发表的10篇文献

Hasan U, .et al. , Research Square, 2023, 13 Apr

Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819

Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143

Jindal A, .et al. , J Transl Sci, 2020, 7: 1-10

Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840

Mariko Fujisawa, .et al. , Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774

Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298

Sunil Kumar Yadava, .et al. , Colloids Surf B Biointerfaces, 2020, Mar 2;190:110927 PMID: 32169777

Takeshi Uenaka, .et al. , Hum Mol Genet, 2018, Nov 15; 27(22): 3974-3985 PMID: 30137437

Yi Xu, .et al. , Free Radic Biol Med, 2016, Jul; 96: 67-77 PMID: 27101738

生物活性

Discription

Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10250
分子式	C21H15ClF4N4O3
分子量	482.8
CAS号	755037-03-7
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	88 mg/mL (182.26 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.71 mL	103.56 mL	207.13 mL
0.5 mM	4.14 mL	20.71 mL	41.43 mL
1 mM	2.07 mL	10.36 mL	20.71 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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