Regorafenib monohydrate

目录号: A15218

Tyrosine kinase 抑制剂

Regorafenib monohydrate

Regorafenib monohydrate Chemical Structure

CAS NO. 1019206-88-2

Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂,IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。

库存: 现货

规格 价格 数量
50 mg
¥ 630.00
100 mg
¥ 840.00
200 mg
¥ 1,330.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂,IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。
In vitro DMSO 93 mg/mL (185.68 mM)
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.97 mL 99.83 mL 199.67 mL
0.5 mM 3.99 mL 19.97 mL 39.93 mL
1 mM 2 mL 9.98 mL 19.97 mL
5 mM 0.4 mL 2 mL 3.99 mL

*The above data is based on the productmolecular weight 500.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15218
作用机制 Inhibitor (抑制剂)
M. Wt 500.83
Formula C21H17ClF4N4O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1019206-88-2
Synonyms BAY 73-4506 monohydrate
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O

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