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Remdesivir也称为GS-5734，在治疗24小时后，其EC50为30 nM抑制鼠肝炎病毒（MHV），并在HAE细胞中以两个74 nM的EC50阻断HAS细胞中的SARS-CoV和MERS-CoV。
| In vitro | DMSO | 96 mg/mL (159.31 mM) | |
| Water | Insoluble | ||
| Ethanol | 15 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.6 mL | 82.98 mL | 165.95 mL |
| 0.5 mM | 3.32 mL | 16.6 mL | 33.19 mL |
| 1 mM | 1.66 mL | 8.3 mL | 16.6 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
*The above data is based on the productmolecular weight 602.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17170 |
|---|---|
| M. Wt | 602.58 |
| Formula | C27H35N6O8P |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1809249-37-3 |
| Synonyms | GS-5734, GS 5734, GS5734 |
| SMILES | CCC(CC)COC([C@H](C)N[P@](OC[C@H]1O[C@](C2=CC=C3N2N=CC=C3N)(C#N)[C@H](O)[C@@H]1O)(OC4=CC=CC=C4)=O)=O |
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