Repotrectinib
目录号: A19850
ROS1/TRK inhibitor
Repotrectinib (TPX-0005) 是一种强效的 ROS1 (IC50=0.07 nM)、TRK (0.83/0.05/0.1 nM=TRKA/B/C) 抑制剂。
ROS1/TRK inhibitor
Discription | Repotrectinib (TPX-0005) is a potent ROS1 (IC50=0.07 nM), TRK (0.83/0.05/0.1 nM=TRKA/B/C) inhibitor. | |||||
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Cell Research |
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目录号 | A19850 |
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分子式 | C18H18FN5O2 |
分子量 | 355.37 |
CAS号 | 1802220-02-5 |
SMILES | O=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3 |
其他名称 | TPX-0005, TPX0005, TP -0005 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 63 mg/mL (177.27 mM) | |
Water | Insoluble | ||
Ethanol | 9 mg/mL (25.32 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 28.14 mL | 140.7 mL | 281.4 mL |
0.5 mM | 5.63 mL | 28.14 mL | 56.28 mL |
1 mM | 2.81 mL | 14.07 mL | 28.14 mL |
5 mM | 0.56 mL | 2.81 mL | 5.63 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2