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Resveratrol具有广泛的靶标，包括环氧合酶（COX，IC50 = 1.1μM），脂氧合酶（LOX，IC50 = 2.7μM），激酶，sirtuins和其他蛋白质。它具有抗癌，抗炎，降低血糖和其他有益的心血管作用。
Targets
| Target | Value | |
|---|---|---|
| SIRT1 | ||
| SIRT2 | ||
| Quinonereductase2 | IC50: 35nM-50nM | |
| IKKβ | IC50: 1μM | |
| DNApolymeraseα | IC50: 3.3μM | |
| LOX | IC50: 3.7μM | |
| DNApolymeraseδ | IC50: 5μM | |
| COX | IC50: 15μM |
| In vitro (25°C) | DMSO | Warmed: 43 mg/mL (188.4 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 43.82 mL | 219.11 mL | 438.21 mL |
| 0.5 mM | 8.76 mL | 43.82 mL | 87.64 mL |
| 1 mM | 4.38 mL | 21.91 mL | 43.82 mL |
| 5 mM | 0.88 mL | 4.38 mL | 8.76 mL |
*The above data is based on the productmolecular weight 228.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10785 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 228.2 |
| Formula | C14H12O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 501-36-0 |
| SMILES | C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O |
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