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Retaspimycin is a potent and water-soluble inhibitor of Hsp90, with EC50s of 119 nM for both Hsp90 and Grp9.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.02 mL | 85.08 mL | 170.15 mL |
| 0.5 mM | 3.4 mL | 17.02 mL | 34.03 mL |
| 1 mM | 1.7 mL | 8.51 mL | 17.02 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 587.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15221 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 587.7 |
| Formula | C31H45N3O8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 857402-23-4 |
| SMILES | OC1=C(C[C@H](C[C@@H]([C@@H]2O)OC)C)C(NCC=C)=C(C=C1NC(/C(C)=C/C=C/[C@@H]([C@H](/C(C)=C/[C@@H]2C)OC(N)=O)OC)=O)O |
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