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Reversine是一种有效的人A3腺苷受体拮抗剂，Ki为0.66μM，是一种泛光A/B/C激酶抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。
靶点信息
| Aurora A | Aurora B | Aurora C | human A3 adenosine receptor | |
| 12 nM | 13 nM | 20 nM | 0.66 μM(Ki) |
| In vitro | DMSO | Warmed: 4 mg/mL (10.17 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.41 mL | 127.06 mL | 254.13 mL |
| 0.5 mM | 5.08 mL | 25.41 mL | 50.83 mL |
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13250 |
|---|---|
| 作用机制 | Inhibitor (抑制剂), Antagonist (拮抗剂) |
| M. Wt | 393.5 |
| Formula | C21H27N7O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 656820-32-5 |
| Synonyms | 0 |
| SMILES | C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5 |
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