RSK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	p70 S6K	p70 S6K1	RSK1	RSK2	RSK3	RSK4	Other Targets
A12452	BI-D1870			**	**	**	***
A10094	AT7867	*						Akt2,PKA,Akt1
A11755	PF-4708671		*
A14373	LJI308			***	****	***
A15527	LY2584702 Tosylate	****
A14202	LY2584702	****
A12464	AT13148	***		*				PKA,ROCK2,ROCK1
A11160	SL 0101-1				**
A14372	LJH685			****	****	****
A11423	FMK				***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SL 0101-1

Catalog No. A11160
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RSK 抑制剂

SL 0101-1是p90核糖体S6激酶（RSK）的选择性抑制剂（对于RSK2，IC50 = 89 nM）。了解更多

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- Pirbhoy PS, .et al. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways, Learn Mem, 2017, Aug; 24(8): 341-357 PMID: 28716954
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PF 4708671

Catalog No. A11755
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S6 kinase 抑制剂

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。了解更多

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- Nogami A, .et al. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway, Transl Oncol, 2018, Nov 22;12(2):336-349 PMID: 30472492
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BI-D1870

Catalog No. A12452
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S6 Kinase 抑制剂

BI-D1870是体外和体内p90核糖体S6激酶（RSK）亚型的有效特异性抑制剂，在体外抑制RSK1，RSK2，RSK3和RSK4的IC50为10–30 nM。了解更多

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- Yuan Xiao Zhu, etc. RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood. 2015 Jan 15; 125(3): 483–491.
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LJH685

Catalog No. A14372
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pan-RSK 抑制剂

LJH685是一种有效，特异性和选择性的RSK抑制剂，可抑制RSK1、2和3的生化活性，IC50为4至13 nM。了解更多

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LJI308

Catalog No. A14373
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RSK 抑制剂

LJI308是一种新型的有效的全RSK抑制剂，对于RSK1，RSK2和RSK3的IC50分别为6 nM，4 nM和13 nM。了解更多

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AT7867

Catalog No. A10094
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AKT 抑制剂

AT7867是AKT和下游激酶p70 S6激酶（p70S6K）以及蛋白激酶A的新型有效抑制剂。了解更多

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FMK

Catalog No. A11423
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RSK 抑制剂

FMK是p90核糖体蛋白S6激酶RSK1和RSK2的有效，高度特异性和不可逆的抑制剂。Fmk结合在CTKD ATP结合位点，并抑制Ser386处的RSK自磷酸化。Fmk诱导人类表达FGFR3的t（4; 14）阳性多发性骨髓瘤细胞发生明显凋亡。了解更多

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- Huang-Ming Chang, .et al. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling, Cell Death Dis, 2021, Apr 17;12(5):409 PMID: 33866326
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AT13148

Catalog No. A12464
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multi-AGC kinase 抑制剂

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。了解更多

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AT7867 2HCl

Catalog No. A15006
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Akt 抑制剂

AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。了解更多

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LY-2584702 tosylate salt

Catalog No. A15527
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p70S6K 抑制剂

LY-2584702 tosylate salt是p70S6K信号传导抑制剂。抑制p70S6K并阻止核糖体S6亚基的磷酸化。了解更多

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LY-2584702

Catalog No. A14202
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p70S6K 抑制剂

LY-2584702是p70S6K信号传导的抑制剂；抑制p70S6K并阻止核糖体S6亚基的磷酸化。了解更多

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BIX-02565

Catalog No. A12692
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RSK2 抑制剂

BIX 02565是核糖体S6激酶2的新型抑制剂，IC50值为1 nM。了解更多

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CMK

Catalog No. A11368
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RSK2 kinase inhibitor

CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. 了解更多

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