Rigosertib
目录号: A21868
multi-kinase inhibitor
Rigosertib(ON-01910)是一种多激酶抑制剂,也是一种选择性抗癌药物,它通过抑制 PI3激酶/Akt通路,促进组蛋白H2AX的磷酸化,并在细胞周期中诱导 G2/M阻滞 来诱导凋亡。
Discription | Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. | |||||
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Cell Research |
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目录号 | A21868 |
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分子式 | C21H25NO8S |
分子量 | 451.49 |
CAS号 | 592542-59-1 |
SMILES | COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O.[(E)] |
其他名称 | ON-01910, ON01910, ON 01910 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2