RITA (NSC 652287)

Name: RITA (NSC 652287)
SKU: A11931
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A11931

p53 activator

1 篇发表文献

RITA，也被称为 NSC 652287，是一种三环噻吩衍生物，它能够结合到 MDM2，打断 MDM2-p53 复合体，随后激活 p53 并诱导凋亡。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥210.00	现货
5mg	¥385.00	现货
10mg	¥630.00	现货
25mg	¥1,330.00	现货
50mg	¥2,485.00	现货
100mg	¥3,710.00	现货
200mg	¥5,215.00	现货
500mg	¥8,015.00	现货
*10mM 1mL in DMSO**	¥525.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用RITA (NSC 652287)发表的1篇文献

M Kobayashi, .et al. , Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340

生物活性

Discription

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11931
分子式	C14H12O3S2
分子量	292.4
CAS号	213261-59-7
SMILES	C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
其他名称	NSC652287, p53 Activator III
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	56 mg/mL (191.53 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (27.36 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.2 mL	171 mL	342 mL
0.5 mM	6.84 mL	34.2 mL	68.4 mL
1 mM	3.42 mL	17.1 mL	34.2 mL
5 mM	0.68 mL	3.42 mL	6.84 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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