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RITA，也称为NSC 652287，是一种三环噻吩衍生物，与MDM2结合，破坏MDM2-p53复合物，随后激活p53，并诱导凋亡。
靶点信息
| Mdm2 | p53 | |||
| In vitro (25°C) | DMSO | 56 mg/mL (191.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL (27.36 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.2 mL | 171 mL | 342 mL |
| 0.5 mM | 6.84 mL | 34.2 mL | 68.4 mL |
| 1 mM | 3.42 mL | 17.1 mL | 34.2 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11931 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 292.4 |
| Formula | C14H12O3S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 213261-59-7 |
| Synonyms | NSC652287, p53 Activator III |
| SMILES | C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO |
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