Ritonavir
目录号: A10799
HIV Protease 抑制剂
Ritonavir 是一种蛋白酶抑制剂，对人类免疫缺陷病毒1型（HIV-1）具有活性。蛋白酶抑制剂阻断HIV中称为蛋白酶的部分。Ritonavir 抑制 HIV 病毒的蛋白酶酶，这阻止了 gag-pol 多蛋白的切割，导致产生非感染性、未成熟的病毒颗粒。
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生物活性
| Discription | Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | |||||
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| Cell Research |
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产品信息
| 目录号 | A10799 |
|---|---|
| 分子式 | C37H48N6O5S2 |
| 分子量 | 720.9 |
| CAS号 | 155213-67-5 |
| SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
| 其他名称 | Norvir, Norvir Softgel |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 94 mg/mL (130.38 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (4.16 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.87 mL | 69.36 mL | 138.72 mL |
| 0.5 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 1 mM | 1.39 mL | 6.94 mL | 13.87 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.77 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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