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RN-1734

产品详情

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM).

溶解度 *

In vitro	DMSO	63 mg/mL (178.31 mM)
	Water	Insoluble
	Ethanol	63 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.3 mL	141.52 mL	283.04 mL
0.5 mM	5.66 mL	28.3 mL	56.61 mL
1 mM	2.83 mL	14.15 mL	28.3 mL
5 mM	0.57 mL	2.83 mL	5.66 mL

*The above data is based on the productmolecular weight 353.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A20616
M. Wt	353.31
Formula	C14H22Cl2N2O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	946387-07-1
Synonyms	RN1734, RN 1734
SMILES	O=S(C1=CC=C(Cl)C=C1Cl)(N(C(C)C)CCNC(C)C)=O