Ro 31-8220 mesylate

Name: Ro 31-8220 mesylate
SKU: A13514
Price: 245 CNY
Rating: 5 (1 reviews)

目录号: A13514

PKC 抑制剂

1 篇发表文献

Ro 31-8220 mesylate 是一种 PKC-抑制剂，它能够抑制由 PKC-激活剂 phorbol myristate acetate（PMA，IC50 = 1.35 x 10(-6) M）或 diacylglycerols（OAG, diC8）诱导的人类中性粒细胞（PMNs）的刺激性液体胞饮作用，抑制率达到95%。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥385.00	现货
5mg	¥630.00	现货
10mg	¥805.00	现货
25mg	¥1,715.00	现货
50mg	¥2,450.00	现货
100mg	¥3,640.00	现货
*10mM 1mL in DMSO**	¥945.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Ro 31-8220 mesylate发表的1篇文献

Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851

生物活性

Discription

Ro 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

Targets

Target	Value

产品信息

目录号	A13514
分子式	C25H23N5O2S.CH3SO3H
分子量	553.7
CAS号	138489-18-6
SMILES	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
其他名称	BIM IX, Bisindolylmaleimide IX (mesylate)
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	85 mg/mL (153.52 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.06 mL	90.3 mL	180.6 mL
0.5 mM	3.61 mL	18.06 mL	36.12 mL
1 mM	1.81 mL	9.03 mL	18.06 mL
5 mM	0.36 mL	1.81 mL	3.61 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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