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RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.4 mL | 141.99 mL | 283.98 mL |
| 0.5 mM | 5.68 mL | 28.4 mL | 56.8 mL |
| 1 mM | 2.84 mL | 14.2 mL | 28.4 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
*The above data is based on the productmolecular weight 352.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20022 |
|---|---|
| M. Wt | 352.14 |
| Formula | C13H8BrF2N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 883093-10-5 |
| Synonyms | RO-4938581, RO4938581 |
| SMILES | FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F |
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