RO4929097
RO4929097 是一种口服生物利用度高的小分子伽马分泌酶（GS）抑制剂，其 IC50 为 4 nM。
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生物活性
| Discription | RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. | |||||
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产品信息
| 目录号 | A10802 |
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| 分子式 | C22H20F5N3O3 |
| 分子量 | 469.4 |
| CAS号 | 847925-91-1 |
| SMILES | CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 92 mg/mL (195.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 16 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween+ddH2O | 9 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.3 mL | 106.52 mL | 213.04 mL |
| 0.5 mM | 4.26 mL | 21.3 mL | 42.61 mL |
| 1 mM | 2.13 mL | 10.65 mL | 21.3 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 847925-91-1 | 847925-91-1 供应商 | 847925-91-1 花费 | 847925-91-1 生产商 | 订购 847925-91-1 | 847925-91-1 代理商