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RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。
靶点信息
| γ secretase (Cell-free assay) | γ secretase(ICN) (Cell-free assay) | Aβ40 (Cell-free assay) | ||
| 4 nM | 5 nM | 14 nM |
| In vitro (25°C) | DMSO | 92 mg/mL (195.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 16 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.3 mL | 106.52 mL | 213.04 mL |
| 0.5 mM | 4.26 mL | 21.3 mL | 42.61 mL |
| 1 mM | 2.13 mL | 10.65 mL | 21.3 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10802 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 469.4 |
| Formula | C22H20F5N3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 847925-91-1 |
| SMILES | CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O |
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