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Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.95 mL | 84.74 mL | 169.48 mL |
| 0.5 mM | 3.39 mL | 16.95 mL | 33.9 mL |
| 1 mM | 1.69 mL | 8.47 mL | 16.95 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.39 mL |
*The above data is based on the productmolecular weight 590.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20593 |
|---|---|
| M. Wt | 590.04 |
| Formula | C29H31ClF3N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1673571-51-1 |
| Synonyms | KAR5585, KAR 5585, KAR-5585 |
| SMILES | ClC1=CC(C2=CC=CC=C2)=C([C@@H](OC3=NC(N)=NC(N4CCC5(CN[C@H](C(OCC)=O)C5)CC4)=C3)C(F)(F)F)C=C1 |
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