Roflumilast

Name: Roflumilast
SKU: A10804

目录号: A10804

PDE 抑制剂

Product Citations (2)

Roflumilast Chemical Structure

CAS NO. 162401-32-3

Roflumilast可作为PDE-4酶的选择性长效抑制剂，无细胞试验中IC50为0.2-4.3 nM。

库存：现货

规格	价格	数量
5 mg	￥ 280.00
10 mg	￥ 455.00
50 mg	￥ 1,260.00
100 mg	￥ 2,100.00
10mM * 1mL in DMSO	￥ 455.00

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生物活性

Roflumilast可作为PDE-4酶的选择性长效抑制剂，无细胞试验中IC50为0.2-4.3 nM。

Targets

Target	Value
PDE4B2	IC50: 0.2nM
PDE4A1	IC50: 0.7nM
PDE4B1	IC50: 0.7nM
PDE4A4	IC50: 0.9nM
PDE4C1	IC50: 3nM
PDE4C2	IC50: 4.3nM

溶解度 *

In vitro (25°C)	DMSO	70 mg/mL (173.6 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (32.24 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.8 mL	124.01 mL	248.02 mL
0.5 mM	4.96 mL	24.8 mL	49.6 mL
1 mM	2.48 mL	12.4 mL	24.8 mL
5 mM	0.5 mL	2.48 mL	4.96 mL

*The above data is based on the productmolecular weight 403.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10804
作用机制	Inhibitor (抑制剂)
M. Wt	403.2
Formula	C17H14Cl2F2N2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	162401-32-3
Synonyms	Daxas, Daliresp
SMILES	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F