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RQ-00203078是一种高度选择性，有效且可口服的TRPM8拮抗剂（大鼠和人类通道的IC50值分别为5.3和8.3 nM），对TRPM8的选择性是TRPV4，TRPV1和TRPA1的> 350倍。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.02 mL | 90.11 mL | 180.23 mL |
| 0.5 mM | 3.6 mL | 18.02 mL | 36.05 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.02 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
*The above data is based on the productmolecular weight 554.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15830 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 554.85 |
| Formula | C21H13ClF6N2O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1254205-52-1 |
| Synonyms | RQ 00203078, RQ00203078 |
| SMILES | ClC1=C(N(CC2=CC=C(OC(F)(F)F)C=C2)S(C3=CC=C(C(O)=O)C=C3)(=O)=O)N=CC(C(F)(F)F)=C1 |
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